Creatine Supplementation Guide

Creatine is a substance that helps increase energy at the cellular level. Without getting too technical we?ll examine how this works. Creatine supplementation has become a science of its own. There are many different theories about whether it works or not, and how it works.

When we look at energy at a cellular level it is created by the creation and breakdown of chains of molecules. ATP (adenosine tri-phosphate) is one of these molecular structures. There are three phosphates attached to the molecule. When a phosphate is separated from the ATP molecule energy is released from the breaking of the connection. This energy is used by the cells. The molecular structure is then changed and what was once ATP becomes ADP (adenosine di-phosphate) with only two phosphates attached. This new molecule begins searching for a free phosphate somewhere to reattach.

The muscles go through three energy phases. The first, and the one we are looking at, is the ATP-PC system where ATP is broken down for energy and rebuilt. This system is the immediate energy system and according to some research can last as long as three minutes, or until all ATP is depleted and there are no free floating phosphates. The next system is the lactic acid system in which the various metabolic processes produce energy and give off lactic acid.

This system last approximately ten to twelve minutes and then the aerobic system kicks in. This system carries the body?s energy needs over extended periods. It is important to note that one system doesn?t stop when the other takes over. They do overlap and the ATP-PC system kicks in every once in a while.

With all of the technical stuff out of the way, let?s look at Creatine and what it does. Creatine introduces phosphates into the energy cycle allowing ATP to be built for a longer amount of time. It is also believed that the body will produce more stored ATP for future use with regular supplementation of Creatine. This allows for a more explosive muscular contraction and a longer lasting ATP cycle. This is important because the muscle contractions are more intense and stronger during the ATP energy cycle.

Creatine is also said to pull more water into the muscles giving them a fuller appearance. This added water also provides more leverage and aids at the cellular level. This increase in water uptake can be dangerous if a person does not drink adequate water during use. Making sure to drink plenty of water keeps the body from becoming dehydrated and enhances the efficiency of the creatine.

There are many different versions of creatine on the market and each claim to work in a different, but better, way than the others. Any product that will introduce more phosphates at the cellular level and increase energy production and release will benefit muscular energy and strength. Whether you are looking for more power while lifting, more explosive take off when sprinting, a longer work capacity or fuller muscles creatine can be an asset to your program.

Source: ezinearticles.com

Creatinine Blood Test

Medical Author: Frederick Hecht, MD, FAAP, FACMG
Medical Editor: William C. Shiel, Jr., MD, FACP, FACR

* What is creatinine?
* Why is it important to check blood creatinine levels?
* What are "normal" blood creatinine levels?

What is creatinine?

Creatinine is a chemical waste molecule that is generated from muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Approximately 2% of the body's creatine is converted to creatinine every day. Creatinine is transported through the bloodstream to the kidneys. The kidneys filter out most of the creatinine and dispose of it in the urine.

Why is it important to check blood creatinine levels?

The kidneys maintain the blood creatinine in a normal range. Creatinine has been found to be a fairly reliable indicator of kidney function. As the kidneys become impaired the creatinine level in the blood will rise. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys, sometimes even before a patient reports any symptoms. It is for this reason that standard blood and urine tests routinely check the amount of creatinine in the blood.

What are "normal" blood creatinine levels?

Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dl) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. (In the metric system, a milligram is a unit of weight equal to one-thousandth of a gram, and a deciliter is a unit of volume equal to one-tenth of a liter.)

Muscular young or middle-aged adults may have more creatinine in their blood than the norm for the general population. Elderly persons, on the other hand, may have less creatinine in their blood than the norm. Infants have normal levels of about 0.2 or more, depending on their muscle development. A person with only one kidney may have a normal level of about 1.8 or 1.9. Creatinine levels that reach 2.0 or more in babies and 10.0 or more in adults may indicate the need for a dialysis machine to remove wastes from the blood.

Certain drugs can sometimes cause abnormally elevated creatinine levels.