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Selegiline (Deprenyl) -
04-17-2007
Selegiline (Deprenyl)
Trivial Name Deprenyl Systematic Name N-methyl-N-(1-methyl-2-phenyl-ethyl)-prop-2-yn-1-amine CAS Number 14611-51-9 ATC Code NO4BD01 Merck Index Number 679321 Chemical Formula C13 H17 N Molecular Weight 187.281 Bioavailability Variable on delivery method Metabolism Hepatic Elimination Half Life 2 hours Excretion Urinary Legal Status Controlled Route of Administration Oral Selegiline (sold under various trade names Deprenyl, Eldepryl or Anipryl [veterinary]) is a drug used for the treatment of early-stage Parkinson's disease and senile dementia. It is also can be used (with reasonable efficacy), as a cognitive enhancer, and many “life-extentionists” use it to treat narcolepsy and as a nootropic. Background Selegiline has been used for years to help Alzheimer's patients, but recently on February 28, 2006, it was approved by the FDA to treat major depression using a transdermal delivery system, and is being looked into for use with ADHD using a patch delivery system also. Action Selegiline, also known as l-deprenyl, is an irreversible and somewhat selective MAO-B inhibitor. It appears to be useful in symptomatic treatment of early Parkinson's disease. Research indicates that Selegiline may also be neuroprotective and act as an antidepressant. Monoamine oxidase helps to maintain neuron firing rates throughout the body within homeostatic limits. It has two primary forms: type A and type B MAO may be inhibited with agents that act reversibly and/or irreversibly as well as selectively and/or unselectively. MAO type-A preferentially deaminates serotonin and noradrenaline, and non-selectively dopamine. Type B metabolises dopamine as wel as phenylethylamine and other assorted trace amines. Through this mechanism of action, Selegiline appears to have a host of neurologically protective effects. Technical Data Selegiline is known to help treat Attention Deficit Hyperactivity Disorder (1) as well as Alzheimer’s disease (2-3). It also seems to increase feelings of well-being in its users (4), as well as acting as a neuroprotector (5) and immune system stimulant (6). Finally, it also acts to alleviate anxiety (7). User Notes Selegiline is one of those drugs that was very popular in track and field because it seemed to boost reaction time, and those athletes can win or lose a sprint by simply reacting more quickly to the starting gun. It’s also very likely that it improves contractile ability of muscles due to it’s ability to improve neuron firing, so it’s got some potential as a strength/speed drug…and since it wasn’t tested for back when it was very popular, it was widely used. I think that for bodybuilders it’s marginally useful because it’s an anti-depressant and helps well-being…both of which can be helpful on heavy cycles. For strength/speed athletes, I think it can be even more beneficial, however, because it can really boost their learning ability when it comes to new skills, improve reaction time, and help them be more efficient. I used this stuff for PCT many years ago (I read about it in my late teens in an article in MM2K). I have to say it does help you learn new skills for a sport more quickly and certainly improved my reaction time. I believe I had been using 5mgs/day and found that to be a decent dose. Unfortunately, use of this drug can cause a false positive for methamphetamine.  References
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