GHRP (growth hormone releasing hormone, GHRH)

GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly.

IGF-2

Actions of IGF-2 are still in research stages. The main difference is that IGF-2 seems to do the same thing as IGF-1 but much faster. When IGF-1 is combined with IGF-2, the body fat results on lab rats were astounding. Growpep is now saying that this peptide is 4x more potent than IGF-1 Lr3.

Obestatin

Published in the November 11th 2005 issue of the Science journal, the study reveals a brand new substance called obestatin that has been found to act as an effective appetite suppressant in lab rats. Ghrelin, a circulating appetite-inducing hormone, is derived from a prohormone by protranslational processing. On the basis of the bioinformatic prediction that another peptide also dervied from pro-ghrelin exists; our source isolated a hormone from rat stomach and named it obestatin- a contradiction of obese, from the Latin "obedere," meaning to devour, and "ststin" denoting suppression. Contrary to the appetite stimulating effects of ghrelin, treatment with rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body weight gain. Obestatin bound to the orphan G protein-coupled receptor GPR39. Thus two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene. After differential modification, these hormones activate distinct receptors.

TGF (transforming growth factor)

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation. However, they play crucial roles in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system.